Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy

• DOI: 10.1155/2015/687938
• Publication Date: 2015-11-19T16:04:20Z
• Authors: Qinyue Guo; Qindong Shi; Huixia Li; Jiali Liu; Shufang Wu; Hongzhi Sun; Bo Zhou
• Keywords: Tauroursodeoxycholic acid

Objective. Tauroursodeoxycholic acid (TUDCA) has been considered an important regulator of energy metabolism in obesity. However, the mechanism underlying how TUDCA is involved insulin resistance not fully understood. We tested effects on autophagic dysfunction obese mice. Material and Methods. 500 mg/kg was injected into mice, metabolic parameters, autophagy markers, signaling molecular were assessed by Western blotting real-time PCR. Results. The injections mice resulted a reduced body weight gain, lower blood glucose, improved sensitivity compared with that vehicle. Meanwhile, treatment only reversed endoplasmic reticulum stress, but also impaired liver Additionally, same results obtained evident treated adenoviral Atg7. Conclusions. found abnormal autophagy, ER restored glycolipid disorder via restoration defective hepatic autophagy.