Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

• DOI: 10.1155/2015/738563
• Publication Date: 2015-08-05T21:04:26Z
• Authors: Natalia M. Bottas...; Marina García; Constanza Bondar; Luciana Guzman; Agustina Redondo; Nestor Chopita; Betina Córsico; Fernando G. Chirdo
• Keywords: Intestinal mucosa; Gluten free; Protein losing enteropathy

Celiac disease (CD) is an immune‐mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed untreated CD patients are linked level and pattern of expression different genes. Fully differentiated epithelial cells express two isoforms fatty acid binding proteins (FABPs): liver, IFABP LFABP, respectively. These bind transport long chain acids also have other important biological roles signaling pathways, particularly those related PPAR γ inflammatory processes. Herein, we analyze serum levels characterize both FABPs protein mRNA small severe normal tissue. As a result, higher circulating compared with controls on gluten‐free diet. In duodenal differential was reduction explained by epithelium loss enteropathy. conclusion, report FABPs’ Consequently, there might be alterations lipid metabolism process mucosa.