Therapeutic Effect of Chenodeoxycholic Acid in an Experimental Rabbit Model of Osteoarthritis

• DOI: 10.1155/2015/780149
• Publication Date: 2015-10-12T23:16:55Z
• Authors: Zhao-wei Yan; Ji Dong; Chen-hao Qin; Chun-yang Zhao; Li-yan Miao; Chun-yan He
• Keywords: Chenodeoxycholic acid; Therapeutic effect

Osteoarthritis (OA) is a slowly progressive joint disease typically seen in middle-age to elderly people. At present, there no ideal agent treat OA. Chenodeoxycholic acid (CDCA) was principal active constituent from animal bile. However, the therapeutic effect of CDCA on OA severity largely unknown. The purpose this study evaluate intra-articular injection rabbit model. induced experimental rabbits by anterior cruciate ligament transection (ACLT) and then were intra-articularly injected with (10 mg/kg or 50 mg/kg) once per week for 5 weeks. results showed that significantly decreased cartilage degradation surface femoral condyles, reducing pathological changes articular synovial membrane macroscopic histological analysis. also bone destruction erosion evaluated micro-CT. Furthermore, could markedly reduce release matrix metalloproteinase-1 (MMP-1), metalloproteinase-3 (MMP-3), interleukin-1 β (IL-1 ), prostaglandin E 2 (PGE ) fluid. These observations highlight might be potential