Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy

• DOI: 10.1155/2015/909827
• Publication Date: 2015-11-09T21:04:40Z
• Authors: David A. DeSantis; Chih-Wei Ko; Lan Wang; Peter Lee; Colleen M. Croniger
• Keywords: NLRC4; Liver Regeneration; Hepatic fibrosis

TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence bacterial components, activating inflammatory cytokines to facilitate clearance pathogens and infected cells. We hypothesized that low-grade constitutive activation may lead induced hepatocyte proliferation prevent fibrosis. gene contains two single nucleotide polymorphisms (SNPs), one located within promoter contained exon 5. These SNPs regulate transcription as measured through reporter assays IL-1 β secretion. 17C-6 mice have increased in plasma after chronic carbon tetrachloride (CCl 4 ) administration compared B6 mice. After two-thirds partial hepatectomy (2/3PH) earlier restoration liver mass with greater cyclin D1 protein BrdU incorporation at several time points. data reveal mild results SNPs, which leads stimulation proliferation. regeneration induces rapid recovery hepatotoxin-induced