Physical Exercise and Redox Balance in Type 2 Diabetics: Effects of Moderate Training on Biomarkers of Oxidative Stress and DNA Damage Evaluated through Comet Assay

• DOI: 10.1155/2015/981242
• Publication Date: 2015-02-19T21:03:32Z
• Authors: Monica Pittaluga; Antonio Sgadari; Ivan Dimauro; Barbara Tavazzi; Paolo Parisi; Daniela Caporossi
• Keywords: Comet Assay

Objective. Hyperglycemia leads to increased production of reactive oxygen species (ROS) in type 2 diabetes, which reduces cellular antioxidant defenses and induces DNA lesions. The aim this study was investigate the effects on redox homeostasis oxidative damage exercise training patients with diabetes compared nondiabetic individuals. Methods Results. 12 sedentary diabetic males (62.1 ± 4.3 yrs) healthy (61.7 3.9 were exposed 4-month moderate training, 3 times per week, evaluate effect plasma biomarkers stress malondialdehyde status (GSSG, GSH/GSSG, ascorbic acid) as well basal H O -induced trough alkaline comet assay peripheral blood lymphocytes. After glutathione acid levels both groups, but only diabetics decreased. Conclusion. Our demonstrates for first time that is not effective improving homeostasis, through an increase endogenous defences patients, also, specifically lowering susceptibility lipid peroxidation levels.