TheCYBAGene⁎49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease

• DOI: 10.1155/2016/1539671
• Publication Date: 2016-05-24T21:15:10Z
• Authors: Tomasz Nowak; Paweł Niemiec; Sylwia Górczyńska...; Anna Balcerzyk; Tomasz Iwanicki; Jolanta Krauze; Wladyslaw Grzeszczak; Anna Ochalska-Tyka; Joanna Iwanicka; Iwona Zak
• Keywords: Adult; Male; 0301 basic medicine; Heterozygote; Genotype; Oligonucleotides; NADPH Oxidases; Coronary Artery Disease; Sequence Analysis, DNA; Middle Aged; Coronary Vessels; Lipids; Polymorphism, Single Nucleotide; 03 medical and health sciences; Risk Factors; Case-Control Studies; Hypertension; Odds Ratio; Humans; Female; Hypertrophy, Left Ventricular; Alleles; Research Article

Purpose. Single nucleotide polymorphisms of theCYBAgene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the⁎49A>G (rs7195830) polymorphism is associated with CAD.Materials and Methods.CYBAgene⁎49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method.Results. The frequency of the⁎49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp.,P=0.020), as well as the frequency of the⁎49G allele (62.2% versus 54.0%,P=0.009). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04–2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08–1.83 for⁎49G versus ⁎49A). Carrier state of the⁎49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50–13.20,P=0.002), as well as the⁎49G allele (OR = 2.25, 95% CI: 1.34–3.77,P=0.001). The⁎49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease (P=0.015).Conclusion. TheCYBAgene⁎49A>G polymorphism modifies the risk of coronary artery disease.