Insulin-Like Growth Factor-1 and Selected Insulin-Like Growth Factor Binding Protein Concentrations during an Ultramarathon Sled Dog Race

• DOI: 10.1155/2016/5686372
• Publication Date: 2016-09-05T21:02:54Z
• Authors: Matthew W. Brunke; Christopher W. Frye; Corri B. Levine; Cristina Hansen; Joseph J. Wakshlag
• Keywords: 0403 veterinary science; Technology; T; Science; Q; R; Medicine; 04 agricultural and veterinary sciences; Research Article

The objective of this study was to investigate the effects running a 1000-mile (1600 km) endurance sled dog race on serum insulin-like growth factor-1 (IGF-1) and factor binding proteins 1 3 (IGFBP-1 IGFBP-3). Serum examined from 12 dogs prior race, at midrace (approximately 690 km), again finish. IGF-1, IGFBP-1, IGFBP-3 were assessed using radioimmunoassay or enzyme linked immune-absorbance assays. Mean prerace concentrations significantly higher than end-race 215.93 ± 80.51 ng/mL, 54.29 25.45 55.53 28.25 respectively (P < 0.001). IGFBP-1 not different across these time periods 24.1 15.8 25.7 14.0 26.6 17.6 respectively. showed modest significant decrease 3,067 2,792 2,626 2,310 2,331 2,301 0.01). Endurance show precipitous drop in IGF-1 concentrations. These differences may be related fuel utilization excessive negative energy balance associated with loss body condition during racing. relative stability suggests that anabolic signaling is diminished ultramarathon Further studies comparing influence duration exercise versus status are warranted better understand differences.