Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications

• DOI: 10.1155/2016/6021428
• Publication Date: 2016-01-03T21:01:40Z
• Authors: Adrienne L. Mueller; Adam Davis; Samantha Sovich; Steven S. Carlson; Farrel R. Robinson
• Keywords: Perineuronal net

Perineuronal nets (PNNs) are extracellular molecules that form around neurons near the end of critical periods during development. They surround neuronal cell bodies and proximal dendrites. PNNs inhibit formation new connections may concentrate rapidly firing inhibitory interneurons. Previous work characterized important role perineuronal in plasticity visual system, amygdala, spinal cord rats. In this study, we use immunohistochemistry to survey distribution representative areas primate brain. We also document changes PNN prevalence these animals different ages. found most prevalent cerebellar nuclei, surrounding >90% there. much less cerebral cortex, than 10% every area examined. The incidence parvalbumin-positive (putative fast-spiking interneurons) varies considerably between Our indicates presence not have a simple relationship with neural serve multiple functions central nervous system.