Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis

• DOI: 10.1155/2017/8601063
• Publication Date: 2017-03-05T16:00:58Z
• Authors: Kh. S. Khaertynov; S. V. Boichuk; S. F. Khaiboullina; V. A. Anokhin; A. A. Andreeva; V. C. Lombardi; M. A. Satrutdinov; E. A. Agafonova; A. A. Rizvanov
• Keywords: Proinflammatory cytokine; Neonatal Sepsis; Pathogenesis

Neonatal sepsis is a significant health issue associated with high mortality. Immune responses neonatal sepsis, such as proinflammatory cytokine production, are believed to play central role in the pathogenesis of this disease. In present study, serum levels cytokines TNF- α , IL1- β and IL-6 anti-inflammatory IL-4 IL-10 were evaluated for 25 subjects sepsis. We observed that late onset (LOS), well those early (EOS), had substantial increase . contrast EOS, LOS demonstrated IL-10. Additionally, we difference profiles between acute postacute cases For instance, level cytokines, IL-6, was elevated phase, whereas production IL-10, became substantially upregulated during phase. no correlation CRP or lymphocyte counts. Thus, counts, examination profile can provide valuable information when determining most effective therapy treating This may be useful physicians if immune stimulatory warranted.