Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

• DOI: 10.1155/2018/8526190
• Publication Date: 2018-11-25T18:31:41Z
• Authors: Huiling Lv; Chao Wu; Xuan Liu; Andi Bai; Yue Cao; Wenjing Shang; Lili Hu; Ying Liu
• Keywords: Liver Cancer

In this study, we prepared PTX-loaded mesoporous hollow SnO 2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a structure. The average outer diameter was 200 nm, the wall thickness 50 nm. DSC XRD study that PTX in channels of present an amorphous state. vitro release experiments demonstrated could efficiently improve dissolution rate PTX. Both cell vivo antitumor SFNFP inhibit growth cells. Therefore, is promising targeting drug delivery carrier.