Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

• DOI: 10.1155/2018/8526190
• Publication Date: 2018-11-25T18:31:41Z
• Authors: Huiling Lv; Chao Wu; Xuan Liu; Andi Bai; Yue Cao; Wenjing Shang; Lili Hu; Ying Liu
• Keywords: 0301 basic medicine; Drug Carriers; Paclitaxel; Liver Neoplasms; Nanofibers; Tin Compounds; Antineoplastic Agents; 3. Good health; Mice; 03 medical and health sciences; Drug Delivery Systems; Folic Acid; Cell Line, Tumor; Animals; Humans; Nanoparticles; Female; Research Article

In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.