Data from Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal Zone

• DOI: 10.1158/0008-5472.c.6505922.v1
• Publication Date: 2024-03-12T18:56:50Z
• Authors: Sara G.M. Piccirillo; Inmaculada Spiteri; Andrea Sottoriva; Anestis Touloumis; Suzan Ber; Stephen J. Price; Richard Heywood; Nicola-Jane Francis; Karen D. Howarth; Vincent P. Collins; Ashok R. Venkitar...; Christina Curtis; John C. Marioni; Simon Tavaré; Colin Watts
• Keywords: Ependymal Cell

<div>Abstract<p>Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis genomic characterization revealed that SEZ harbors malignant cells tumor-initiating capacity, analogous to isolated from tumor mass (T). We observed resistance supramaximal chemotherapy doses along differential patterns drug response between T same tumor. Our results reveal novel insights into glioblastoma growth dynamics, implications for understanding limiting resistance. <i>Cancer Res; 75(1); 194–202. ©2014 AACR</i>.</p></div>