Data from Dietary Microbes Modulate Transgenerational Cancer Risk

• DOI: 10.1158/0008-5472.c.6507905.v1
• Publication Date: 2023-03-31T22:41:48Z
• Authors: Theofilos Poutahidis; Bernard J. Varian; Tatiana Levkovich; Jessica R. Lakritz; Sheyla Mirabal; Caitlin Kwok; Yassin M. Ibrahim; Sean M. Kearney; Antonis Chatzigia...; Eric J. Alm; Susan E. Erdman
• Keywords: 2. Zero hunger; 3. Good health

<div>Abstract<p>Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' <i>in utero</i> dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. <i>Cancer Res; 75(7); 1197–204. ©2015 AACR</i>.</p></div>