Data from Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma

• DOI: 10.1158/0008-5472.c.6508575.v1
• Publication Date: 2023-03-31T22:34:58Z
• Authors: Coralie Allain; Gaëlle Angenard; Bruno Clément; Cédric Coulouarn
• Keywords: Liver Cancer; Gene signature

<div>Abstract<p>Integrative genomics helped characterize molecular heterogeneity in hepatocellular carcinoma (HCC), leading to targeted drug candidates for specific HCC subtypes. However, no consensus was achieved genes and pathways commonly altered HCC. Here, we performed a meta-analysis of 15 independent datasets (<i>n</i> = 784 human HCC) identified comprehensive signature consisting 935 deregulated as compared with the surrounding nontumor tissue. In signature, upregulated were linked early genomic alterations hepatocarcinogenesis, particularly gains 1q 8q. The covered well-established cancer hallmarks, such proliferation, metabolic reprogramming, microenvironment remodeling, together hallmarks associated protein turnover epigenetics. Subsequently, enabled us assess efficacy signature-relevant candidates, including histone deacetylase inhibitors that specifically reduced viability six cell lines. Overall, this integrative approach recurrently may be by drugs. Combined therapies targeting common subtype-specific networks represent relevant therapeutic strategy liver cancer. <i>Cancer Res; 76(21); 6374–81. ©2016 AACR</i>.</p></div>