Data from Loss of Tumor Suppressor <i>STAG2</i> Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells

• DOI: 10.1158/0008-5472.c.6508956.v1
• Publication Date: 2023-03-31T22:17:46Z
• Authors: Zharko Daniloski; Susan Smith
• Keywords: Chromosome instability

&lt;div&gt;Abstract&lt;p&gt;Sister chromatids are held together by cohesin, a tripartite ring with peripheral SA1/2 subunit, where SA1 is required for telomere cohesion and SA2 centromere cohesion. The &lt;i&gt;STAG2&lt;/i&gt; gene encoding often inactivated in human cancer, but not manner associated aneuploidy. Thus, how these tumors maintain chromosomal loss contributes to tumorigenesis remain open questions. Here we show that, despite cohesion, sister mutant tumor cells mitosis at chromosome arms telomeres. Telomere maintenance occurred either recombination or telomerase activation mechanisms. Notably, were refractory inhibitors, indicating can provide an alternative means of maintenance. silencing normal that lack led increased telomeres, delayed shortening, postponed senescence onset. Insofar as shortening replicative prevent genomic instability cancer limiting the number cell divisions, our findings suggest extending lifespan due inactivation could promote period during which tumor-driving mutations occur. &lt;i&gt;Cancer Res; 77(20); 5530–42. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;