Data from Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery

• DOI: 10.1158/0008-5472.c.6509981
• Publication Date: 2023-03-31T02:57:47Z
• Authors: Huang-Chiao Huang; Imran Rizvi; Joyce Liu; Sriram Anbil; Ashish Kalra; Helen Lee; Yan Baglo; Nancy Paz; Douglas Hayden; Steve Pereira; Brian W. Pogue; Jonathan Fitzgerald; Tayyaba Hasan
• Keywords: Priming (agriculture); Tumor progression

<div>Abstract<p>Physiologic barriers to drug delivery and selection for resistance limit survival outcomes in cancer patients. In this study, we present preclinical evidence that a subtumoricidal photodynamic priming (PDP) strategy can relieve the tumor microenvironment safely widen therapeutic window of nanoformulated cytotoxic drug. orthotopic xenograft models pancreatic cancer, combining PDP with nanoliposomal irinotecan (nal-IRI) prevented relapse, reduced metastasis, increased both progression-free 1-year disease-free survival. enabled these durable improvements by targeting multiple compartments (i) increase intratumoral accumulation >10-fold, (ii) duration exposure above critical threshold, (iii) attenuate surges CD44 CXCR4 expression, which mediate chemoresistance often observed after multicycle chemotherapy. Overall, our results offer proof concept effectiveness minimize risks progression, extend patient survival.</p><p><b>Significance:</b> A biophysical approach overcomes key treatment barriers, significantly reduces metastases, prolongs human cancer. <i>Cancer Res; 78(2); 558–71. ©2017 AACR</i>.</p></div>