Data from Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis

• DOI: 10.1158/0008-5472.c.6511184
• Publication Date: 2023-03-31T05:16:04Z
• Authors: Emeline Ragonnaud; Kanako Moritoh; Monica Bodogai; Fedor Gusev; Soizic Garaud; Chen Chen; Xin Wang; Tuvshintugs Balji...; Kevin G. Becker; Robert W. Maul; Karen Willard-Gallo; Evgeny Rogaev; Arya Biragyn
• Keywords: Thymic stromal lymphopoietin

<div>Abstract<p>Immature B cells in the bone marrow emigrate into spleen during adult lymphopoiesis. Here, we report that emigration is shifted to earlier B-cell stages mice with orthotopic breast cancer, spontaneous ovarian and possibly human carcinoma. Using mouse aspirates models challenged highly metastatic 4T1 cancer cells, demonstrated this was result of secretion thymic stromal lymphopoietin (TSLP) by cells. First, TSLP downregulated surface expression (BM) retention receptors CXCR4 VLA4 precursors, increasing their motility and, presumably, emigration. Then, supported peripheral survival proliferation BM precursors such as pre-B–like used increased pool circulating generate metastasis-supporting regulatory As such, loss alone or TSLPR deficiency blocked both accumulation circulation metastasis, implying pre-B cell–TSLP axis can be an attractive therapeutic target.</p>Significance:<p>Cancer induce premature from cells.</p></div>