Data from A Model of Indirect Cell Death Caused by Tumor Vascular Damage after High-Dose Radiotherapy

• DOI: 10.1158/0008-5472.c.6511233.v1
• Publication Date: 2023-03-31T05:22:42Z
• Authors: Pedro Rodríguez-B...; Pablo Díaz-Botana; Araceli Gago-Arias; Manuel Feijoo; Sara Neira; Jacobo Guiu-Souto; Óscar López-Pouso; Antonio Gómez-Caa...; Juan Pardo-Montero
• Keywords: Hypoxia; Tumor Hypoxia

<div>Abstract<p>There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms cell death. Such effect seems to be two-fold. High may an immune response and cause vascular damage, leading starvation Development mathematical models, including death, help clinicians design SBRT optimal schedules. Despite experimental literature on tumor death caused by efforts modeling this have been limited. In work, we present a biomathematical model effect. our model, oxygenation obtained solving the reaction–diffusion equation; kills cells according linear–quadratic also endothelial (EC), which can loss functionality capillaries. Capillary will affect oxygenation, driving nearby into severe hypoxia. Capillaries recover due EC proliferation. Tumor entering predetermined hypoxia status die hypoxia-death model. This fits recently published data showing damage surviving fractions. It fraction curves qualitatively reproduces values percentages functional capillaries 48 hours postirradiation, hypoxic pre- postirradiation. useful for exploring aspects constitutes stepping stone toward accounting during planning.</p>Significance:<p>A novel radiation could potentially interpret better schedules.</p></div>