Data from CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia

• DOI: 10.1158/0008-5472.c.6816237.v1
• Publication Date: 2023-09-01T08:55:50Z
• Authors: Thomas Farge; Jean Nakhle; Damien Lagarde; Guillaume Cognet; Nathaniel Polley; Rémy Castellano; Marie-Laure Nicolau; Claudie Bosc; Marie Sabatier; Ambrine Sahal; Estelle Saland; Yannick Jeanson; Nathan Guiraud; Emeline Boet; Camille Bergoglio; Mathilde Gotanègre; Pierre-Luc Mouchel; Lucille Stuani; Clément Larrue; Marie Sallese; Véronique De Mas; Cedric Moro; Cédric Dray; Yves Collette; Isabelle Raymond-...; Isabelle Ader; Christian Récher; Jean-Emmanuel Sarry; Florence Cabon; François Vergez; Audrey Carrière
• Keywords: CD36; Scavenger Receptor

<div>Abstract<p>Identifying mechanisms underlying relapse is a major clinical issue for effective cancer treatment. The emerging understanding of the importance metastasis in hematologic malignancies suggests that it could also play role drug resistance and acute myeloid leukemia (AML). In cohort 1,273 AML patients, we uncovered multifunctional scavenger receptor CD36 was positively associated with extramedullary dissemination leukemic blasts, increased risk after intensive chemotherapy, reduced event-free overall survival. dispensable lipid uptake but fostered blast migration through its binding thrombospondin-1. CD36-expressing which were largely enriched exhibited senescent-like phenotype while maintaining their migratory ability. xenograft mouse models, inhibition blasts prolonged survival chemotherapy-treated mice. These results pave way development as an independent marker poor prognosis patients promising actionable target to improve outcome patients.</p>Significance:<p>CD36 promotes disease represents critical can be exploited patient treatment.</p></div>