Data from Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer

• DOI: 10.1158/0008-5472.c.6908384.v1
• Publication Date: 2023-11-01T08:15:21Z
• Authors: Zhihang Chen; Guopei Zhang; Xiaoxue Ren; Zhijia Yao; Qian Zhou; Xuxin Ren; Shuling Chen; Lixia Xu; Kaiyu Sun; Qianwen Zeng; Ming Kuang; Dong-Ming Kuang; Sui Peng

<div>Abstract<p>The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we demonstrated that are regulator hepatocellular carcinoma (HCC) colorectal cancer metastasis (CRLM) microenvironments. displayed distinct developmental trajectories HCC CRLM. Single-cell analysis revealed IgG<sup>+</sup> plasma preferentially accumulated HCC, whereas IgA<sup>+</sup> were enriched Mechanistically, recruited by tumor-associated macrophages via the CXCR3–CXCL10 axis, CRLM metastatic CCR10–CCL28 signaling. Functionally, promoted protumorigenic formation induced granulocytic myeloid-derived suppressor activation Clinically, increased infiltration was correlated to worse survival, intratumoral neutrophils indicated poor prognosis. Taken together, this study myeloid cell-mediated immunosuppression CRLM, suggesting selectively modulating or tumor-related immunosuppressive regulatory networks might reprogram provide immunotherapeutic strategy for treating cancer.</p>Significance:<p>The immunomodulatory patterns tumor-infiltrating cancer, with mediating physiologic processes drive progression.</p></div>