Data from The Associations between Intakes of One-Carbon Metabolism–Related Vitamins and Breast Density among Young Women

• DOI: 10.1158/1055-9965.c.7162252
• Publication Date: 2024-04-03T07:20:49Z
• Authors: Eunyoung Han; Linda Van Horn; Linda Snetselaar; John A. Shepherd; Yoon Jung Park; Hyesook Kim; Seungyoun Jung; Joanne F. Dorgan
• Keywords: Breast density

<div>AbstractBackground:<p>Folate is the primary methyl donor and B vitamins are cofactors for one-carbon metabolism that maintain DNA integrity epigenetic signatures implicated in carcinogenesis. Breast tissue particularly susceptible to stimuli early life. Only limited data available on associations of metabolism–related vitamin intake during youth young adulthood with breast density, a strong risk factor cancer.</p>Methods:<p>Over 18 years DISC DISC06 Follow-up Study, diets 182 women were assessed by three 24-hour recalls five occasions at ages 8 once 25 29 years. Multivariable-adjusted linear mixed-effects regression was used examine intakes metabolism-related MRI-measured percent dense volume (�V) absolute (ADBV) years.</p>Results:<p>Folate inversely associated �V (<i>P</i><sub>trend</sub> = 0.006) ADBV 0.02). These inverse observed post-, though not premenarche. In contrast, premenarche B2 positively < 0.001). Young adult folate B6 (all <i>P</i><sub>trend</sub> ≤ 0.04), whereas B12 0.04).</p>Conclusions:<p>Among these participants density. Larger prospective studies among diverse populations needed replicate findings.</p>Impact:<p>Our results suggest importance life development density thereby potentially cancer later life.</p></div>