Data from Differential DNA Methylation in the Benign and Cancerous Prostate Tissue of African American and European American Men

• DOI: 10.1158/1055-9965.c.7700635
• Publication Date: 2025-03-03T08:56:48Z
• Authors: Meytal Chernoff; Kathryn Demanelis; Marc Gillard; Dayana Delgado; Kevin J. Gleason; Meritxell Oliva; Lin Chen; Anthony Williams; Russel Z. Szmulewitz; Donald J. Vander ...; Brandon L. Pierce

<div>AbstractBackground:<p>African American (AA) men are at increased risk of prostate cancer compared with European (EA) men. Biological mechanisms, including epigenetics, likely contribute to this disparity, but prior studies have been limited by sample size, candidate gene approaches, or lack epigenome-wide DNA methylation (DNAm) data.</p>Methods:<p>To improve our understanding these we DNAm features distinguishing tumor and paired histologically benign tissue from 76 AA 75 EA patients cancer. We generated genome-wide array-based data conducted differential analyses comparing tissues in each ancestry group. then examined the predictive ability identified sites group.</p>Results:<p>We 90,747 98,929 differentially methylated CpGs EA, respectively, 76,400 common both groups. 6,267 genes promoters ancestries 639 1,301 unique as well pathways. Only 10 were needed distinguish based on a receiver operating characteristic curve (AUC > 0.9), one accurately predicting versus other also ancestry-associated (89 tumor, 423 benign).</p>Conclusions:<p>Methylation similar for men; however, subtle differences identified.</p>Impact:<p>Differences may reveal growth strategies, an important area future disparities research.</p></div>