Data from The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas

• DOI: 10.1158/1078-0432.c.6740546.v1
• Publication Date: 2023-07-13T13:01:07Z
• Authors: Karolin Heinze; Evan S. Cairns; Shelby Thornton; Bronwyn Harris; Katy Milne; Marcel Grube; Charlotte Meyer; Anthony N. Karnezis; Sian Fereday; Dale W. Garsed; Samuel C.Y. Leung; Derek S. Chiu; Malak Moubarak; Philipp Harter; Florian Heitz; Jessica N. McAlpine; Anna DeFazio; David D.L. Bowtell; Ellen L. Goode; Malcolm Pike; Susan J. Ramus; C. Leigh Pearce; Annette Staebler; Martin Köbel; Stefan Kommoss; Aline Talhouk; Brad H. Nelson; Michael S. Anglesio
• Keywords: Serous carcinoma; Clear cell carcinoma

<div>AbstractPurpose:<p>Endometrioid ovarian carcinoma (ENOC) is the second most-common type of carcinoma, comprising 10%–20% cases. Recently, study ENOC has benefitted from comparisons to endometrial carcinomas including defining with four prognostic molecular subtypes. Each subtype suggests differential mechanisms progression, although tumor-initiating events remain elusive. There evidence that microenvironment may be critical early lesion establishment and progression. However, while immune infiltrates have been well studied in high-grade serous studies are limited.</p>Experimental Design:<p>We report on 210 ENOC, clinical follow-up annotation. Using multiplex IHC immunofluorescence, we examine prevalence T-cell lineage, B-cell macrophages, populations programmed cell death protein 1 or death-ligand across subtypes ENOC.</p>Results:<p>Immune tumor epithelium stroma showed higher densities known high mutation burden (<i>POLE</i>mut MMRd). While were prognostically significant, not (overall survival <i>P</i> > 0.2). Analysis by revealed density was significant only <i>no specific profile</i> (NSMP) subtype, where lacking B cells (TIL<sub>B minus</sub>) had inferior outcome (disease-specific survival: HR, 4.0; 95% confidence interval, 1.1–14.7; < 0.05). Similar carcinomas, stratification generally superior response predicting outcomes.</p>Conclusions:<p>Subtype for better understanding particular distribution significance infiltrates. The role within NSMP tumors warrants further study.</p></div>