Data from The prognostic effect of immune cell infiltration depends on molecular subtype in Endometrioid Ovarian Carcinomas

• DOI: 10.1158/1078-0432.c.6740546
• Publication Date: 2023-07-13T13:01:09Z
• Authors: Karolin Heinze; Evan S. Cairns; Shelby Thornton; Bronwyn Harris; Katy Milne; Marcel Grube; Charlotte Meyer; Anthony N. Karnezis; Sian Fereday; Dale W. Garsed; Samuel C.Y. Leung; Derek S. Chiu; Malak Moubarak; Philipp Harter; Florian Heitz; Jessica N. McAlpine; Anna DeFazio; David D.L. Bowtell; Ellen L. Goode; Malcolm Pike; Susan J. Ramus; C. Leigh Pearce; Annette Staebler; Martin Köbel; Stefan Kommoss; Aline Talhouk; Brad H. Nelson; Michael S. Anglesio
• Keywords: Ovarian carcinomas; Infiltration (HVAC)

<div>Abstract<p>Purpose: Endometrioid ovarian carcinoma (ENOC) is the second most-common type of carcinoma, comprising 10-20% cases. Recently, study ENOC has benefitted from comparisons to endometrial carcinomas (EC) including defining with four prognostic molecular subtypes. Each subtype suggests differential mechanisms progression, though tumor initiating events remain elusive. There evidence that microenvironment may be critical early lesion establishment and progression. However, while immune infiltrates have been well studied in high-grade serous studies are limited. Experimental Design: We report on 210 ENOC, clinical follow-up annotation. Using multiplex immunohistochemistry immunofluorescence, we examine prevalence T cell lineage, B macrophages, populations PD-1 or PD-L1 across subtypes ENOC. Results: Immune epithelium stroma showed higher densities known high mutation burden (<i>POLE</i>mut MMRd). While were prognostically significant, not (OS p>0.2). Analysis by revealed density was significant only <i>no specific subtype</i> (NSMP) subtype, where lacking cells (TIL<sub>B minus</sub>) had inferior outcome (DSS HR:4.0 CI 1.1-14.7, p<0.05). Similar EC, stratification generally superior response predicting outcomes. Conclusions: Subtype for better understanding particular distribution significance infiltrates. The role within NSMP tumors warrants further study.</p></div>