Data from Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery

• DOI: 10.1158/1078-0432.c.7054077
• Publication Date: 2024-02-01T08:21:16Z
• Authors: Roy Hajjar; Manon Oliero; Gabriela Fragoso; Ayodeji Samuel Ajayi; Ahmed Amine Alaoui; Hervé Vennin Rendos; Annie Calvé; Thibault Cuisiniere; Claire Gerkins; Sophie Thérien; Nassima Taleb; François Dagbert; Herawaty Sebajang; Rasmy Loungnarath; Frank Schwenter; Richard Ratelle; Ramses Wassef; Eric De Broux; Carole Richard; Manuela M. Santos

<div>AbstractPurpose:<p>Anastomotic leak (AL) is a major complication in colorectal cancer surgery and consists of the leakage intestinal content through poorly healed colonic wound. Colorectal recurrence after determinant survival. We hypothesize that AL may allow cells to escape gut lead improving anastomotic healing prevent local implantation metastatic dissemination cells.</p>Experimental Design:<p>We investigated association between postoperative outcomes patients with cancer. Using mouse models poor healing, we assessed processes cells. The effect dietary supplementation inulin 5-aminosalicylate (5-ASA), which activate PPAR-γ gut, on tumors was mice undergoing surgery. Inulin 5-ASA were also model liver metastasis.</p>Results:<p>Patients experiencing displayed lower overall oncologic survival than non-AL patients. Poor led larger peritoneal tumors. microbiota displays capacity antineoplastic gut. Modulation using reinforced barrier prevented spread mice.</p>Conclusions:<p>Our findings reinforce hypothesis preventing paramount Furthermore, they pave way toward targeting as novel enhance diminish recurrence.</p></div>