FOXA1 Expression in Breast Cancer—Correlation with Luminal Subtype A and Survival

• DOI: 10.1158/1078-0432.ccr-07-0122
• Publication Date: 2007-08-01T18:19:18Z
• Authors: Sunil Badve; Dmitry Turbin; Mangesh A. Thorat; Akira Morimiya; Torsten O. Nielsen; Charles M. Perou; Sandi Dunn; David G. Huntsman; Harikrishna Naksh...
• Keywords: FOXA1

Abstract Purpose: FOXA1, a forkhead family transcription factor, is essential for optimum expression of ∼50% estrogen receptor α (ERα):estrogen responsive genes. FOXA1 expressed in breast cancer cells. It segregates with genes that characterize the luminal subtypes DNA microarray analyses. The utility as possible independent prognostic factor has not been determined cancers. Materials and Methods: A tissue comprising tumors from 438 patients 15.4 years median follow-up was analyzed by immunohistochemistry. Interpretable obtained 404 along other factors like tumor grade, size, nodal status, ER, progesterone (PR), HER2/neu. Results: (score >3) seen 300 cancers it correlated ER (P = 0.000001), PR 0.00001), subtype 0.000001). Loss noted worsening grade 0.001). Univariate analysis showed status 0.0000012), size 0.0004), 0.012) to be predictors cancer–specific survival. Multivariate only 0.001) 0.039) significant factors, whereas 0.060) 0.131) were significant. In patient subgroup, associated better cancer-specific survival 0.024) ER-positive predictor 0.009) than 0.213). Conclusion: correlates tumors. Prognostic ability these low-risk may prove useful clinical treatment decisions.