Data from Triple Primary Cancers: An Analysis of Genetic and Environmental Factors

• DOI: 10.1158/1940-6207.c.7213929
• Publication Date: 2024-05-02T07:49:05Z
• Authors: Nicholas A. Borja; Rachel Silva-Smith; Carmen Calfa; Daniel A. Sussman; Mustafa Tekin
• Keywords: Primary (astronomy); Triple-negative breast cancer

<div>Abstract<p>The occurrence of multiple primary cancers (MPC) is thought to reflect increased cancer susceptibility in patients due a combination genetic and environmental factors. Here we conducted retrospective review 2,894 consecutive evaluated at single institution identified 31 (1.14%) individuals with history three or more cancers, then analyzed the influences associated their propensity for developing malignancies. We found that 35.5% had hereditary syndrome (HCS), high penetrance HCS 72.7% cases, suggesting monogenic causes underly significant proportion triple risk. Analysis frequencies diagnosis breast was significantly lower likelihood HCS, while colorectal, prostate, pancreas higher HCS. Comparison HCS-positive HCS-negative revealed similar demographic characteristics, mean age first diagnosis, family cancer. Moreover, no differences lifestyle behaviors, occupational exposures, chronic health conditions, treatment chemotherapy radiation were observed between -negative groups, though outliers tobacco smoking, as well systemic after both second observed. These findings indicate robust contribution among less evident. This emphasizes need larger MPC cohorts incorporating additional factors comprehensively characterize drivers risk.</p>Prevention Relevance:<p>In predisposition explained cases; however, history, habits, other exposures appeared play role. highlights value early screening develop sensitive markers susceptibility.</p><p><i><a href="https://aacrjournals.org/cancerpreventionresearch/article/doi/10.1158/1940-6207.CAPR-24-0115" target="_blank">See related Spotlight, p. 193</a></i></p></div>