Data from Acute Influenza Infection Promotes Lung Tumor Growth by Reprogramming the Tumor Microenvironment

• DOI: 10.1158/2326-6066.c.6534828.v1
• Publication Date: 2023-04-03T13:50:24Z
• Authors: Irati Garmendia; Aditi Varthaman; Solenne Marmier; Mahmud Angrini; Ingrid Matchoua; Aurelie Darbois-D...; Nathalie Josseaume; Pierre-Emmanuel Foy; Lubka T. Roumenina; Naïra Naouar; Maxime Meylan; Sophie Sibéril; Jules Russick; Pierre-Emmanuel J...; Karen Leroy; Diane Damotte; Audrey Mansuet-Lupo; Marie Wislez; Marco Alifano; Laurie Menger; Ignacio Garcia-Ve...; Jean-Michel Salle...; Olivier Lantz; Florent Petitprez; Isabelle Cremer
• Keywords: Reprogramming; Tumor progression

<div>Abstract<p>One billion people worldwide get flu every year, including patients with non–small cell lung cancer (NSCLC). However, the impact of acute influenza A virus (IAV) infection on composition tumor microenvironment (TME) and clinical outcome NSCLC is largely unknown. We set out to understand how IAV load impacts growth modifies cellular molecular players in TME. Herein, we report that can infect both immune cells, resulting a long-term protumoral effect tumor-bearing mice. Mechanistically, impaired tumor-specific T-cell responses, led exhaustion memory CD8<sup>+</sup> T cells induced PD-L1 expression cells. modulated transcriptomic profile TME, fine-tuning it toward immunosuppression, carcinogenesis, lipid drug metabolism. Consistent these data, transcriptional module by mice was also found human adenocarcinoma correlated poor overall survival. In conclusion, worsened progression reprogramming TME more aggressive state.</p></div>