Data from Differential Expression of Homing Receptor Ligands on Tumor-Associated Vasculature that Control CD8 Effector T-cell Entry

• DOI: 10.1158/2326-6066.c.6548726.v1
• Publication Date: 2023-04-04T19:55:41Z
• Authors: Amber N. Woods; Ashley L. Wilson; Nithya Srivinisan; Jianhao Zeng; Arun B. Dutta; J. David Peske; Eric F. Tewalt; Randal K. Gregg; Andrew R. Ferguson; Victor H. Engelhard
• Keywords: Addressin; Homing (biology); CXCR3

<div>Abstract<p>Although CD8<sup>+</sup> T cells are critical for controlling tumors, how they recruited and home to primary metastatic lesions is incompletely understood. We characterized the homing receptor (HR) ligands on tumor vasculature determine what drives their expression role in T-cell entry. The anatomic location of B16-OVA tumors affected E-selectin, MadCAM-1, VCAM-1, whereas HR CXCL9 ICAM-1 were expressed regardless location. VCAM-1 was induced by IFNγ-secreting adaptive immune cells. CXCL9/10 enabled effectors expressing α<sub>4</sub>β<sub>1</sub> integrin CXCR3 enter both subcutaneous peritoneal E-selectin ligand<sup>+</sup> tumors. However, MadCAM-1 did not mediate α<sub>4</sub>β<sub>7</sub><sup>+</sup> effector entry into due an unexpected lack luminal expression. These data establish relative importance certain HRs activated effective control <i>Cancer Immunol Res; 5(12); 1062–73. ©2017 AACR</i>.</p></div>