Data from Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies

• DOI: 10.1158/2326-6066.c.6550716
• Publication Date: 2023-04-04T16:08:34Z
• Authors: Li Song; Zhangyi Ouyang; David Cohen; Yang Cao; Jennifer Altreuter; Gali Bai; Xihao Hu; Kenneth J. Livak; Heng Li; Ming Tang; Bo Li; X. Shirley Liu
• Keywords: Cancer Immunotherapy

<div>Abstract<p>We applied our computational algorithm TRUST4 to assemble immune receptor (T-cell receptor/B-cell receptor) repertoires from approximately 12,000 RNA sequencing samples The Cancer Genome Atlas and seven immunotherapy studies. From over 35 million assembled complete complementary-determining region 3 sequences, we observed that the expression of <i>CCL5</i> <i>MZB1</i> is most positively correlated genes with T-cell clonal expansion B-cell expansion, respectively. We analyzed amino acid evolution during somatic hypermutation identified tyrosine as preferred residue. found IgG1+IgG3 antibodies together FcRn were associated complement-dependent cytotoxicity antibody-dependent cellular or phagocytosis. In addition infiltration, discovered are also better patient outcomes. Finally, created a website, VisualizIRR, for users interactively explore visualize in this study.</p><p><i><a href="https://dx.doi.org/10.1158/2326-6066.CIR-22-0403" target="_blank">See related Spotlight by Liu Han, p. 786</a></i></p></div>