Fig. S14 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

• DOI: 10.1158/2767-9764.23509006.v1
• Publication Date: 2023-06-13T14:25:49Z
• Authors: Kazunori Aoki; Yukari Nishito; Noriko Motoi; Yasuhito Arai; Nobuyoshi Hiraoka; Tatsuhiro Shibata; Yukiko Sonobe; Yoko Kayukawa; Eri Hashimoto; Mina Takahashi; Etsuko Fujii; Takashi Nishizawa; Hironori Fukuda; Kana Ohashi; Kosuke Arai; Yukihiro Mizoguchi; Yukihiro Yoshida; Shun-ichi Watanabe; Makiko Yamashita; Shigehisa Kitano; Hiromi Sakamoto; Yuki Nagata; Risa Mitsumori; Kouichi Ozaki; Shumpei Niida; Yae Kanai; Akiyoshi Hirayama; Tomoyoshi Soga; Toru Maruyama; Keisuke Tsukada; Nami Yabuki; Mei Shimada; Takehisa Kitazawa; Osamu Natori; Noriaki Sawada; Atsuhiko Kato; Teruhiko Yoshida; Kazuki Yasuda; Hideaki Mizuno; Hiroyuki Tsunoda; Atsushi Ochiai

<p>Activated and suppressed pathways identified by GSEA with GO gene set in respective immune subtypes. (a, b) Heatmap representing top scored pathways enriched in genes showing commonly increased and decreased expression in respective immune subtypes in LUAD (a) and LUSQ (b). Top signaling pathways for genes showing increased expression are presented in red and those for genes showing decreased expression are presented in blue. (c, d) Running enrichment score with GO gene set of blood vessel morphogenesis, epidermis development, keratinocyte differentiation, and T cell activation signatures as the activated pathways in respective immune subtypes of LUAD (c) and LUSQ (d).</p>