FIGURE 4 from The African-centric P47S Variant of <i>TP53</i> Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition

• DOI: 10.1158/2767-9764.23661343.v1
• Publication Date: 2023-07-11T14:21:35Z
• Authors: David C. Stieg; Joshua L. D. Parris; Tyler Hong Loong ...; Gauri Mirji; Sarah Kim Reiser; Nivitha Murali; Madison Werts; Thibaut Barnoud; David Y. Lu; Rahul Shinde; Maureen E. Murphy; Daniel T. Claiborne
• Keywords: CD86; CD11c

&lt;p&gt;Tumor-bearing S47 mice harbor more immunosuppressive splenic immune cell profiles. &lt;b&gt;A,&lt;/b&gt; Flow cytometry analyses on splenocytes from TBM for percent positive MDSCs in P47 and mice, respectively. Bar graph right shows the out of total CD45&lt;sup&gt;+&lt;/sup&gt; cells. &lt;i&gt;n&lt;/i&gt; = 5 per group. &lt;b&gt;B,&lt;/b&gt; indicated activation markers macrophages spleen. Histograms top show mean fluorescent intensity (MFI) MHC I histograms bottom MFI CD86. The red solid line indicates filled histogram sample. bar graphs quantitative data. &lt;b&gt;C&lt;/b&gt; &lt;b&gt;D,&lt;/b&gt; Expression CD86 by CD11c&lt;sup&gt;+&lt;/sup&gt;CD103&lt;sup&gt;+&lt;/sup&gt; DCs CD19&lt;sup&gt;+&lt;/sup&gt; B cells, respectively, spleens TBM, shown as MFI. Statistics were derived two-tailed Student &lt;i&gt;t&lt;/i&gt; tests. *, &lt;i&gt;P&lt;/i&gt; &lt; 0.05.&lt;/p&gt;