FIGURE 1 from The African-centric P47S Variant of <i>TP53</i> Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition

• DOI: 10.1158/2767-9764.23661352.v1
• Publication Date: 2023-07-11T14:22:23Z
• Authors: David C. Stieg; Joshua L. D. Parris; Tyler Hong Loong ...; Gauri Mirji; Sarah Kim Reiser; Nivitha Murali; Madison Werts; Thibaut Barnoud; David Y. Lu; Rahul Shinde; Maureen E. Murphy; Daniel T. Claiborne

&lt;p&gt;The tumor growth advantage in S47 mice is abolished following CD8&lt;sup&gt;+&lt;/sup&gt; T-cell depletion. &lt;b&gt;A,&lt;/b&gt; Illustration of the experimental approach. Replicate P47 and were injected subcutaneously with 1 × 10&lt;sup&gt;6&lt;/sup&gt; MC38 cells. At day 19, spleens tumors from harvested analyzed by flow cytometry. &lt;b&gt;B,&lt;/b&gt; Tumor curves for &lt;i&gt;n&lt;/i&gt; = 5 per group. Linear mixed model used statistical analysis. **, &lt;i&gt;P&lt;/i&gt; &lt; 0.01. &lt;b&gt;C,&lt;/b&gt; weights mice. Wilcoxon rank-sum test *, 0.05. &lt;b&gt;D&lt;/b&gt; &lt;b&gt;E,&lt;/b&gt; cells, ± treatment anti-CD8b antibody. &lt;b&gt;F,&lt;/b&gt; The percentage T cells total (CD45&lt;sup&gt;+&lt;/sup&gt;/CD3&lt;sup&gt;+&lt;/sup&gt;) before after depletion shown on left. Shown right are counts splenic depletion.&lt;/p&gt;