FIGURE 1 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

• DOI: 10.1158/2767-9764.24119262
• Publication Date: 2023-09-11T14:21:55Z
• Authors: Richard W. Davis; Astero Klampatsa; Gwendolyn M. Cramer; Michele M. Kim; Joann M. Miller; Min Yuan; Cassandra Houser; Emma Snyder; Mary Putt; Sergei A. Vinogradov; Steven M. Albelda; Keith A. Cengel; Theresa M. Busch

<p>Surgical resection, although necessary, limits the achievable PDT response of residual disease. Murine mesothelioma AB12 cells were implanted in flanks female syngeneic mice. <b>A,</b> Mice with 200 mm<sup>3</sup> tumors that surgically debulked by 60% (to ∼80 mm<sup>3</sup>) prior to (<i>n</i> = 10) achieved CRs (no regrowth after 90 days) and showed longer times than mice whose treated alone 5; <i>P</i> 0.115) or 0.008). <b>B,</b> bearing either 30% 90% 8) treatment absence 4 each). For PDT, a larger extent cytoreduction significantly increased rate (<i>P</i> 0.014). <b>C,</b> CR rates numerically higher received at 80 versus those grown 10, shown again from A). <b>D,</b> Tumors exposed TI creating skin flap incision across longest diameter. administered (TI/PDT, <i>n</i> worse 20; 0.022).</p>