FIGURE 7 from Sigma1 Regulates Lipid Droplet–Mediated Redox Homeostasis Required for Prostate Cancer Proliferation

• DOI: 10.1158/2767-9764.24460572.v2
• Publication Date: 2023-10-30T15:27:42Z
• Authors: Halley M. Oyer; Alexandra R. Steck; Charles G. Longen; Sanjana Venkat; Konuralp Bayrak; Eleanor B. Munger; Dan Fu; Paola A. Castagnino; Christina M. Sanders; Nathalia A. Tancler; My T. Mai; Justin P. Myers; Matthew J. Schiewer; Nan Chen; Elahe A. Mostaghel; Felix J. Kim

<p>GSEA and correlation analysis of Sigma1/<i>SIGMAR1</i> in prostate tumors. GSEA using Adipogenesis and ROS Pathway Hallmark gene sets on localized prostate tumors from TCGA (<b>A</b>; <a href="#bib60" target="_blank">60</a>) and metastatic prostate tumors from SU2C/PCF Dream Team (<b>B</b>; <a href="#bib61" target="_blank">61</a>). <b>C,</b> Heat map of normalized enrichment scores from primary, metastatic, or benign prostate tissue utilizing TCGA, MSKCC, SU2C/PCF Dream Team, and FHCRC datasets (<a href="#bib60 bib61 bib63" target="_blank">60, 61, 63</a>). <b>D,</b> Single gene correlation analysis between <i>SIGMAR1</i> and <i>PNPLA2</i>, <i>BCSL2,</i> and <i>PLIN5</i> using Z-scores from published primary prostate tumor datasets (<a href="#bib60 bib63 bib64" target="_blank">60, 63, 64</a>).</p>