Data from <i>FASN</i> Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

• DOI: 10.1158/2767-9764.c.7031724.v1
• Publication Date: 2024-01-18T14:31:48Z
• Authors: Oluwademilade Dairo; Lia DePaula Oliveira; Ethan Schaffer; Thiago Vidotto; Adrianna A. Mendes; Jiayun Lu; Sophie Vo Huynh; Jessica Hicks; Adam G. Sowalsky; Angelo M. De Marzo; Corrine E. Joshu; Brian Hanratty; Karen S. Sfanos; William B. Isaacs; Michael C. Haffner; Tamara L. Lotan

&lt;div&gt;Abstract&lt;p&gt;Fatty acid synthase (FASN) catalyzes the synthesis of long-chain saturated fatty acids and is overexpressed during prostatic tumorigenesis, where it therapeutic target in several ongoing trials. However, mechanism FASN upregulation prostate cancer remains unclear. Here, we examine &lt;i&gt;FASN&lt;/i&gt; gene CpG methylation pattern by InfiniumEPIC profiling whole-genome bisulfite sequencing across multiple racially diverse primary metastatic cohorts, comparing with protein expression as measured digitally quantified IHC assay reverse phase array analysis or expression. We demonstrate that body hypomethylated tumors compared benign tissue, significantly inversely correlated both cancer. Primary &lt;i&gt;ERG&lt;/i&gt; rearrangement have increased find evidence hypomethylation this context. also from carriers germline &lt;i&gt;HOXB13&lt;/i&gt; G84E mutation matched controls, consistent a report HOXB13 may contribute to epigenetic regulation &lt;i&gt;in vitro&lt;/i&gt;. contrast previous studies, no significant association self-identified race models include status two independent tumor cohorts. Taken together, these data support potential for which be relevant selecting patients responsive inhibitors.&lt;/p&gt;Significance:&lt;p&gt;Here, leverage cohorts highly This finding shed light on mechanisms provides potentially useful biomarker future trials inhibitors.&lt;/p&gt;&lt;/div&gt;