Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles

• DOI: 10.1158/2767-9764.crc-22-0057
• Publication Date: 2022-08-05T14:06:31Z
• Authors: Yitian Xu; Licheng Zhang; Jose Thaiparambil; Sunny Mai; Dimuthu Nuwan Perera; Jilu Zhang; Ping-Ying Pan; Cristian Coarfa; Kenneth Ramos; Shu-Hsia Chen; Randa El-Zein
• Keywords: 0301 basic medicine; Medical Sciences; Lung Neoplasms; Cell Phenomena; Racial Groups; Life Sciences; 610; White; 3. Good health; Medical Cell Biology; Black or African American; 03 medical and health sciences; Medical Microbiology; Medical Molecular Biology; Medical Specialties; Medicine and Health Sciences; Tumor Microenvironment; and Immunity; Humans; Biological Phenomena; Research Article

Tumors accumulated with infiltrated immune cells (hot tumors) have a higher response rate to checkpoint blockade, when compared those minimal T-cell infiltration (cold tumors). We report here that patients lung cancer different racial backgrounds harbored distinct cell profiles in the tumor microenvironment. Compared African Americans (AA), Caucasian (CA) exhibited increased and vasculature, survival. Changes of survival profile were most pronounced among active smokers nonsmokers, former total patients. Neighborhood analysis showed around CAs but not AAs. Our findings reveal intrinsic biological differences between AA CA cancer, suggesting treatment plans should be tailored for backgrounds.We where Caucasians present hot microenvironment cold Treatment customized maximize therapeutic outcomes.