Gamma Knife Radiosurgery for Pituitary Adenomas

• DOI: 10.1159/000056446
• Publication Date: 2003-04-15T19:06:20Z
• Authors: M. Hayashi; M. Izawa; H. Hiyama; S. Nakamura; S. Atsuchi; H. Sato; K. Nakaya; K. Sasaki; T. Ochiai; O. Kubo; T. Hori; K. Takakura
• Keywords: Adenoma; Adult; Male; Time Factors; Middle Aged; Radiosurgery; Disease-Free Survival; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Acromegaly; Humans; Female; Pituitary Neoplasms; Prolactinoma; Visual Fields; Cushing Syndrome; Aged; Follow-Up Studies; Retrospective Studies

Ninety-two patients with pituitary adenomas have been treated during the last 5 years. Sixty-three of these patients had more than 6 months follow-up, and they form the basis of this report. Eighteen had non-functioning adenomas (NFA), and 36 had functioning adenomas (FA). The mean marginal dose was 22.5 Gy (NFA 19.5 Gy, FA 23.9 Gy). Control of tumor growth was achieved in 92%. A significant decrease of excessive hormone production was seen in 75.6%, and the endocrinopathy normalization rate was 26.7%. Post-radiosurgical complications were seen in 4.7%.