Dietary Pulverized Konjac Glucomannan Suppresses Scratching Behavior and Skin Inflammatory Immune Responses in NC/Nga Mice

• DOI: 10.1159/000103220
• Publication Date: 2007-05-25T13:05:53Z
• Authors: Nobukazu Onishi; Seiji Kawamoto; Hidenori Suzuki; Hiroyuki Santo; Tsunehiro Aki; Seiko Shigeta; Kunihiko Hashimoto; Michihiro Hide; Kazuhisa Ono
• Keywords: Scratching; Proinflammatory cytokine

Feeding with pulverized konjac glucomannan (PKGM) suppresses the development of eczema and hyper-IgE production in NC/Nga mice, a model atopic dermatitis. This study aimed to examine effects PKGM on scratching behavior skin inflammatory immune responses mice.Four-week-old mice were maintained for 8 or 9 weeks diet containing PKGM. Scratching clinical symptoms evaluated every 2 weeks. Effects cutaneous inflammation by histopathological analysis. Local expression levels substance P proinflammatory cytokines measured ELISA.An increase was evident from 6 age control but this symptom dose-dependently inhibited PKGM-fed mice. Continuous feeding then significantly eczematous lesions including hyperkeratosis, dermal mastocytosis eosinophilia. Concomitantly, overproductions P, IL-10, IL-4, TNF-alpha all suppressed mice.PKGM markedly behavior, mastocytosis,