Sex Steroid Receptor Expression Profile in Brown Adipose Tissue. Effects of Hormonal Status

• DOI: 10.1159/000110448
• Publication Date: 2007-10-26T08:01:08Z
• Authors: Sergio Rodriguez-...; Marta Monjo; Marga Frontera; Magdalena Gianotti; Ana Maria Proenza; Pilar Roca
• Keywords: Sex steroid; Sex hormone receptor; Steroid hormone

Recent investigations suggest that sex hormones play an important role in the brown adipose tissue (BAT) thermogenic program by acting on several steps of lipolytic signal cascade and UCP1 transcription control. However, number studies focusing steroid receptor status is negligible. In present study, we analyze mRNA levels male female rats pregnant lactating females, all them models with a different hormonal background. The direct effect expression their receptors was studied vitro primary culture adipocytes. Oestrogen (ERα) androgen (AR) densities were higher than BAT. PR A+B downregulated lactation, suggesting progesterone signalling thermogenesis impairment at this stage. showed decreased testosterone ERα mRNA. results highlighted study demonstrate presence BAT cell cultured adipocytes, supporting idea changes would be for understanding hormone effects physiology.