Treatment of Lupus Nephritis by Mycophenolate Mofetil

• DOI: 10.1159/000316321
• Publication Date: 2010-07-21T07:03:20Z
• Authors: Violeta Rabrenović; Mileta Poskurica; Zoran Kovačević; Vidosava Nešić; Marina Savin; Branka Mitić; Nada Dimković; Čedomir Čučković; Danica Vujić; Steva Plješa; Gordana Peruničić...; Slobodan Čurić; Igor Mitić; Marina Ratković; Jelena Marinković; Dragan Jovanović
• Keywords: Mycophenolate; Maintenance therapy; Nephritis

<i>Background/Aims:</i> Mycophenolate mofetil (MMF) has been increasingly used for the treatment of lupus nephritis (LN). The aim this study was to examine efficacy and safety MMF with low doses corticosteroids as maintenance therapy in patients LN. <i>Methods:</i> covered 35 patients, most them proliferative types LN (5 WHO class III, 26 IV), while 1 had V 3 VI nephritis. administered dose 1.5–2 g/24 h prednisone at 10–20 mg/day. effects were followed over a 12-month period. <i>Results:</i> After months significant reduction proteinuria achieved (2.1 ± 2.4 vs. 1.0 h, p < 0.01) maintained end study. In parallel, rise serum albumin, fall cholesterol increase mean glomerular filtration rate noted. Complete remission 16 (45.7%), including all III plus 10 IV. Not single adverse effect observed. <i>Conclusion:</i> combined steroids is an effective safe stable