High Prevalence of <i>Helicobacter pylori</i> Infection in Greek Patients with Myelodysplastic Syndromes

• DOI: 10.1159/000319629
• Publication Date: 2010-10-11T07:06:34Z
• Authors: Michael D. Diaman...; Elizabeth Ioannid...; Jannis Kountouras; Eudokia Mandala; Georgios Tsapournas; Ifigenia Frida-Mi...; Philippos Klonizakis; Christos Zavos; Styliani Haralamb...; Efthymia Vlachaki; Efthymia Parapani...; Ioannis Klonizakis
• Keywords: Male; 0303 health sciences; Greece; Helicobacter pylori; Middle Aged; Helicobacter Infections; 3. Good health; Causality; Cohort Studies; Leukemia, Myeloid, Acute; 03 medical and health sciences; Antigens, CD; Case-Control Studies; Myelodysplastic Syndromes; Humans; Female; Lymphocytes; Aged

<i>Background/Aims/Methods:</i> To determine the frequency of <i>Helicobacter pylori</i> infection (<i>Hp</i>-I) in 73 patients with myelodysplastic syndromes (MDS) and 40 controls, serologic analyses of <i>Hp</i> and ¹³C-urease breath tests (INFAI) were performed. Gastric mucosal biopsy specimens were obtained to determine the presence of <i>Hp</i>-I using a rapid urease test, i.e. the Campylobacter-like organism (CLO) test, and cresyl violet staining. Peripheral blood (PB) flow cytometry for CD3, CD4, CD8, CD14, CD19 and CD34 was conducted in 35 patients and in controls. <i>Results:</i><i>Hp</i>-I was detected by: (a) serology in 75.34% of patients (p = 0.000), (b) INFAI in 57.69% of patients, (c) CLO in 60.71% of patients and (d) histological confirmation in 80.36% of patients (p = 0.001). No correlation between <i>Hp</i>-I and CD3, CD4, CD8, CD14, CD19 expression, leukemic transformation or death was observed. However, in 20 cases, significant variation in the PB lymphocytic proportion possibly attributable to<i> Hp</i>-I was ascertained, in contrast to the expected MDS ratio. <i>Conclusion:</i> Although there is no evidence for a causal relationship between <i>Hp</i>-I and MDS, the increased prevalence of <i>Hp</i>-I among the MDS patients is an interesting finding that deserves further investigation as it may indicate a common factor causing susceptibilities to both MDS and <i>Hp</i>-I or that <i>Hp</i> might influence the pathophysiology of MDS.