Role for Target of Rapamycin (mTOR) Signal Pathway in Regulating Neuronal Injury after Intracerebral Hemorrhage

• DOI: 10.1159/000455983
• Publication Date: 2017-05-04T21:03:20Z
• Authors: Jie-Ping Wang; Meng-Yu Zhang
• Keywords: Ribosomal protein s6; RPTOR; RHEB

Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase and activation its signal pathway plays an important role in regulating growth synthesis as well cell proliferation survival. In the present study, we examined contribution mTOR downstream products to brain injuries induced by intracerebral hemorrhage (ICH) rats.Western Blot analysis was employed examine expression Caspase-3. ELISA used measure pro-inflammatory cytokines (PICs) vascular endothelial factor (VEGF). Additionally, neurological Severity Score water content were indicate function edema.The p-mTOR, mTOR-mediated phosphorylation 4E-binding 4 (4E-BP1), p70 ribosomal S6 1 (S6K1) pathways amplified ICH rats compared with controls. Blocking using significantly attenuated upregulation PICs, namely IL-1β, IL-6 TNF-α, Caspase-3 indicating apoptosis, promoted levels VEGF subtype receptor VEGFR-2 tissues. Moreover, effects linked improvement deficits increased observed rats.Activation engaged pathophysiological process during blocking beneficial neuronal tissues via PIC, apoptotic mechanisms. This has pharmacological implications specific for dysfunction vulnerability related ICH.