<b><i>ABCB1</i></b> and <b><i>SLCO1B3</i></b> Gene Polymorphisms and Their Impact on Digoxin Pharmacokinetics in Atrial Fibrillation Patients among the Tunisian Population

• DOI: 10.1159/000457906
• Publication Date: 2017-02-16T22:06:14Z
• Authors: Nejia Tounsi; Imen Trabelsi; Emna Kerkeni; Mohamed Habib Grissa; Nizar Fredj; Adel Sekma; Malek Mzali; Ilhem Hellara; Kamel Monastiri; Wahiba Douki; Semir Nouira
• Keywords: Adult; Aged, 80 and over; Male; Digoxin; ATP Binding Cassette Transporter, Subfamily B; Tunisia; Genotype; Middle Aged; Organic Anion Transporters, Sodium-Independent; Polymorphism, Single Nucleotide; 3. Good health; Solute Carrier Organic Anion Transporter Family Member 1B3; 03 medical and health sciences; 0302 clinical medicine; Atrial Fibrillation; Humans; Female; Aged

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Digoxin is a substrate of P-glycoprotein (P-gp) and organic anion transporting polypeptide transporters that are encoded by &lt;i&gt;ABCB1&lt;/i&gt; &lt;i&gt;SLCO1B3&lt;/i&gt; genes. Genetic polymorphisms in both genes may explain inter-individual variability serum digoxin concentration (SDC). This study evaluates the possible effect most common on SDC after single oral dose Tunisian atrial fibrillation (AF) patients. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt;&lt;i&gt;ABCB1&lt;/i&gt; genotypes were analyzed 102 patients with AF who received (0.5 mg) without (group I, &lt;i&gt;n&lt;/i&gt; = 58) or co-administration P-gp inhibitors II, 44). SDCs determined at 6 h following dose. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; levels significantly higher co-administered inhibitors. No influence was noted group I However, values different among nucleotide (SNPs) 2677G&gt;T/A (TT, GG&gt;GT, &lt;i&gt;p&lt;/i&gt; &lt; 0.05) 3435C&gt;T CC&gt;CT, only II no 1236C&gt;T SNPs. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Results suggest gene affect pharmacokinetics.