Recurrence of Pemphigus Vulgaris after Bilateral Breast Irradiation: A Case Report and Review of the Literature

• DOI: 10.1159/000520380
• Publication Date: 2021-11-30T22:13:30Z
• Authors: Camille Invernizzi; Victor Gaultier; Philippe Guilbert; Christelle Jouannaud; Anne-Laure Labrousse; Charles Marchand ...
• Keywords: Pemphigus vulgaris; Mucocutaneous zone; Lumpectomy; Paraneoplastic pemphigus

Pemphigus is a serious and rare chronic bullous autoimmune disease. It characterized by mucocutaneous erosions secondary to autoantibodies directed against desmogleins 1 3, proteins involved in intercellular adhesion mechanisms. The occurrence of pemphigus based on the triggering genetic external environmental factors such as drugs, infection, more rarely radiotherapy. To date, only 16 cases radiation-induced are described context breast cancer treatment. We present case 76-year-old woman who had recurrence vulgaris limited irradiation field after exposure an adjuvant radiotherapy treatment for bilateral triple-negative cancer. onset was area treated effectively with local systemic corticosteroids. After rigorous review literature, appeared. In contrast several cases, rash irradiated improved For than three-quarters occurs within 3 months following end immunosuppressive treatment, this disease disappears vast majority reported cases.