ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome

• DOI: 10.1160/th07-04-0296
• Publication Date: 2007-10-16T10:04:21Z
• Authors: Corinne Frere; Thomas Cuisset; Jacques Quilici; Laurence Camoin; Joseph Carvajal; Pierre Emmanuel M...; Marc Lambert; Irène Juhan-Vague; Jean-Louis Bonnet; Marie-Christine A...
• Keywords: ST elevation

Clopidogrel responsiveness has been proposed to be involved in recurrent ischemic events after stenting for non-ST elevation acute coronary syndromes (NSTE ACS). However, its biological definition is not consensual. We assess the value of ADP-induced platelet aggregation (ADP-Ag) and reactivity index VASP (PRI VASP) predicting patients with NSTE ACS undergoing percutaneous intervention (PCI). studied 195 consecutive PCI a 600 mg loading dose clopidogrel. ADP-Ag PRI were analysed. The primary end-point was within 30 days PCI. It occurred 14 (7%). Construction ROC curves examine predictive models showed that sensitivity specificity endpoint 79% 76%, respectively, maximal intensity >or=70%, 93% 50% PRIVASP > 53%. positive negative values 21% 98%, 12% 99% In PCI, identify low responders clopidogrel an increased risk respective cut-off 70%