Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation

• DOI: 10.1160/th08-09-0577
• Publication Date: 2009-01-19T09:35:01Z
• Authors: Sabine Steiner; Daniela Seidinger; Renate Koppensteiner; Thomas Gremmel; Simon Panzer; Christoph Kopp
• Keywords: Quartile

Summary A high on-treatment residual ADP-inducible platelet reactivity in light transmission aggregometry (LTA) has been associated with an increased risk of adverse outcomes after percutaneous coronary intervention (PCI). However, LTA is weakly standardized, and results obtained one laboratory may not be comparable to those another one. We therefore sought determine the test correlating best estimate clopidogrel-mediated inhibition 80 patients on dual antiplatelet therapy elective stent implantation. selected VerifyNow P2Y12 assay, vasodilator-stimulated phosphoprotein phosphorylation multiple electrode Impact-R for comparisons LTA. Cut-off values were defined according quartiles each assay. Sensitivities specificities different function tests based from The all four assays correlated significantly assay revealed strongest correlation (r = 0.61, p < 0.001). ranged 35% 55%, 78.3% 85%, respectively. In conclusion, although LTA, they need improved become clinically used diagnostic tests. Further, it too early define gold standard method assessing generally acceptable cut-off values.