Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques

• DOI: 10.1160/th11-05-0368
• Publication Date: 2011-11-10T10:49:34Z
• Authors: Olivier Meilhac; Ivan Bièche; Pierre Raynal; Patrick Bruneval; Jean-Baptiste Michel; Delphine Borgel; Sylvain Clauser
• Keywords: GAS6; Proinflammatory cytokine

Summary Vitamin K-dependent protein Gas6 (growth-arrest specific gene 6) plays a role in vascular smooth muscle cell (VSMC) survival and migration, as well endothelium leukocyte activation, could therefore be involved atherosclerosis. However, the study of mouse models has led to contradictory results regarding pro- or anti-atherogenic properties Gas6, relatively few data are available human pathophysiology. To better understand implication atherosclerosis, we studied expression secretion vitro VSMC, analysed effect on inflammatory these cells. We show that VSMC is strongly induced by anti-inflammatory cytokine transforming growth factor (TGF)β, stimulation recombinant decreases genes tumour necrosis (TNF)α intracellular adhesion molecule (ICAM)-1. The carotid endarterectomy samples revealed mainly expressed at all stages but not detected normal vessel wall. Analysis plaque secretomes showed markedly higher non-complicated plaques than complicated plaques, TGFβ pattern mirrors Gas6. conclude secreted atherosclerotic following TGFβ, with complication. Therefore, propose acts protective factor, part reducing pro-inflammatory phenotype VSMC.