Effects of thrombopoietin receptor agonists on procoagulant state in patients with immune thrombocytopenia

• DOI: 10.1160/th13-10-0873
• Publication Date: 2014-07-03T07:27:21Z
• Authors: María Teresa Álva...; Ihosvany Fernánde...; Elena G. Arias-Sa...; María Isabel Riva...; Víctor Jiménez Yuste; Mónica Martín Salces; Nora V. Butta
• Keywords: Thrombopoietin receptor; Eltrombopag

Thrombopoietin receptor agonists (TPO-RA) have recently been introduced for the treatment of immune thrombocytopenia (ITP), an anti-platelet-antibodies autoimmune disease. The observation a low frequency bleeding episodes despite their suggests existence compensatory mechanism. This study aimed to evaluate effect TPO-RA on platelet function and procoagulant state in ITP patients before (ITP-bR) after responding (ITP-aR) treatment. Plasma- microparticle (MP)-associated capacity from was similar regimen but higher than healthy control values. High MP-associated activity did not seem be due increased activation, since stimulation by reduced ITP-bR ITP-aR patients. It could related apoptosis, evaluated terms surface phosphatidylserine (PS), observed both groups. In summary, count ameliorate change plasma- patient responders this therapy.