Fibrin clot properties and haemostatic function in men and women with type 1 diabetes

• DOI: 10.1160/th14-05-0404
• Publication Date: 2014-10-16T09:06:23Z
• Authors: Gun Jörneskog; Anna Ågren; Per-Eric Lins; Håkan Wallén; Aleksandra Antovic; Sara Tehrani
• Keywords: Adult; Male; 0301 basic medicine; Fibrin; Hemostasis; Fibrinolysis; Microcirculation; Fibrinogen; Middle Aged; Permeability; 3. Good health; Diabetes Complications; 03 medical and health sciences; Diabetes Mellitus, Type 1; Cardiovascular Diseases; Nephelometry and Turbidimetry; Risk Factors; Hyperglycemia; Humans; Female; Blood Coagulation Tests; Blood Coagulation; Aged

The increased risk of vascular complications in type 1 diabetes may part be explained by changes haemostatic function. In the present study, we investigated fibrin clot properties patients with relation to sex and microvascular complications. study included 236 (107 women) aged between 20-70 years without any history cardiovascular disease. Fibrin properties, assessed determination permeability coefficient (Ks) turbidimetric clotting lysis assays, did not differ men women. Compared men, women had worse glycaemic control as well higher levels prothrombin fragment 1+2 peak thrombin generation vitro, indicating both vivo vitro. Subgroup analyses younger than 30 revealed less permeable clots prolonged time females compared age-matched men. Patients fibrinogen concentrations denser clots. Thus, conclude that vitro disease are different sexes, but associate prevalence Tighter formation women, suggested our results, affect their future should a larger population.