Speciation and antifungal susceptibility of Candida isolates from diabetic foot ulcer patients in a tertiary hospital in Kenya

• DOI: 10.11604/pamj.2022.41.34.30815
• Publication Date: 2022-01-13T10:21:53Z
• Authors: Victor Moses Musyoki; Winnie Mutai; Nancy Ngugi; Fredrick Otieno; Moses Muia Masika
• Keywords: Candida dubliniensis; Diabetic foot ulcer; Flucytosine

diabetic foot ulcer is the leading cause of hospital admissions, lower limb amputation and death among patients. Little information available on fungal isolation in patients, especially sub-Saharan Africa. This study aimed to describe Candida species infecting ulcers patients receiving clinical care at Kenyatta National Hospital assess their antifungal susceptibility profile.this was a cross-sectional carried out adult over three-month period. Species identification performed using VITEK - 2 System further confirmed by Matrix-Assisted Laser Desorption Ionization-Time Flight Mass Spectrometry. Antifungal testing determined VITEK-2 System. Data were analysed WHONET SPSS.among 152 recruited, 98% (n=149) had type diabetes. Sixty one percent participants male. The mean age 50.7 years (SD 12.9). A total 36 isolated, which 75% (n=27) albicans. lusitaniae (8%, n=3) C. dubliniensis (5%, n=2) predominant non-albicans species. overall prevalence candidiasis 20% (n=31). albicans isolates (26%) resistant caspofungin, fluconazole, micafungin, voriconazole but highly susceptible amphotericin B flucytosine (81-96%). Non-albicans isolated (90-100%) majority agents tested.Candida showed low resistance rates commonly administered agents. There need include diagnosis investigation infection.